POS0565 IS ACTIVE SYNOVITIS OF METACARPOPHALANGEAL JOINTS A NEUROPATHIC CONDITION IN RHEUMATOID ARTHRITIS PATIENTS? RESULTS FROM A ULTRASOUND STUDY AT LEVEL OF THE PALMAR DIGITAL NERVES

Background: Rheumatoid arthritis (RA) is a chronic inflammatory that primarily affects the joints of hands, wrists, and feet. Anatomical damage (at bone, cartilage tendon level) occurs as consequence persistent synovial inflammation (1). In RA, periarticular soft tissues, including nerves, may also be involved. particular, there high prevalence neuropathic conditions such carpal tunnel syndrome (CTS) in RA patients. fact, presence changes can frequently documented by ultrasound (US) at level median nerve (2). Currently available very-high frequency US transducers allow spatial resolution small anatomical structures, palmar digital nerves. Objectives: The objectives this study were: to document dimensional alterations particularly terms increased cross-sectional area (CSA), determine variables associated with CSA, Methods: From September 2020 December 2020, adult patients from tertiary outpatient clinic were consecutively included regardless disease activity status. Patients underwent clinical assessment using Clinical Disease Activity Index (CDAI), functional capacity QuickDASH, pain features PainDetect Questionnaire (PDQ). same visit, examination 2 nd 5 th metacarpophalangeal (MCPj) clinically more involved hand an operator blinded assessment. presence/absence grading synovitis was recorded for each joint. A third operator, joint assessment, measured CSA pair nerves finger scanned involvement. MCPj. examinations conducted MyLab Class C (Esaote, Genoa, Italy), 6-18 MHz probe articular examination, 10-22 serological status, respectively rheumatoid factor (RF) anti-citrullinated peptide antibodies (ACPA), radiographic erosive patient. Statistical analysis considering sum finger. compared respect body mass index (BMI), duration, activity, grading, capacity, features, characteristics, Results: Sixty-three included, 48 women, 15 men, mean age 62.2 (11.8, standard deviation [SD]) years, duration 10.9 (8.2) total 252 MCPj 504 taken individually 2.3 (0.9) mm , ranging 1 8 4.2 (1.5) There statistically significant association assessed CDAI (p <0.001), while no associations any other variables. Conclusion: active both ultrasonographic indices, correlates This alteration probably due mechanisms perineural tissues Active during somehow framed condition capable causing References: [1]Filippucci E, Cipolletta Mashadi Mirza R, et al. Ultrasound imaging arthritis. Radiol Med 2019;124(11):1087-1100. [2]Smerilli G, Di Matteo A, idiopathic syndrome. Clin Rheumatol 2020; doi: 10.1007/s10067-020-05293-z. Disclosure Interests: None declared